Angst, Alzheimers, Crohns, diabetes, hovedpine, gigt, fibromyalgi, paradentose, sclerose kan hamp virke på. Vidt forskellige sygdomme med en ting tilfælles: At de kan reguleres med en enkelt plante.
Af Benedikte Mikkelsen
Artiklen blev bragt i magasinet sund-forskning – oktober/november 2018
Hampeplantens unikke virkestoffer, cannabinoider, lader til at virke nærmest universelt på både mennesker og dyr. Cannabinoider findes i cellekernen og udfører flere vigtige funktioner. Når cannabinoider indtages, genkender vores celler dem, som var det vores egne stoffer. Det forklares ved, at kroppen selv har medfødte cannabinoider, også kaldet endocannabinoider. Der er millioner af dem i krop og hjerne. Cannabinoiden er i bund og grund en kraftig antioxidant. Men hvor de fleste kendte antioxidanter såsom vitamin C kun har en funktion på celleplan, har cannabinoider utallige funktioner. Cannabinoider regulerer mange systemer i kroppen, og den regulerer behovet. Lider en person eksempelvis af spiseforstyrrelser, kan appetitten øges ved at indtage cannabinoider, mens en overvægtig vil få mindre appetit.
Når immunforsvaret angriber sig selv
Cannabinoider lader til, af samme grund som beskrevet ovenfor, at være effektive mod autoimmune sygdomme. Cannabinoider kan ikke alene øge immunforsvaret, men også sænke det. Derfor er der flere, der oplever, at cannabis har en positiv effekt på autoimmune sygdomme, såsom psoriasis og gigt, hvor immunforsvaret angriber sig selv.
Endocannabinoider bliver naturligt aktiveret ved behov, afhængigt af aktiviteten. Hos mange er endocannabinoide-systemet ikke stimuleret nok, og derfor kan man have behov for tilførsel af cannabinoider fra cannabisplanten.
Naturens smertestillere
Cannabissens smertestillende virkning har vist sig at være så effektiv i kliniske studier, at den kan sammenlignes med kraftige opiater i både potens og effektivitet. Cannabinoider lader til at kunne undertrykke reaktioner på akutte skadelige stimuli som ved slag, inflammatoriske smerter og nerveskader, via CB1 receptorer.
Svaret på et af neurofysiologiens største gåder
I 2001 skete et vigtigt gennembrud i cannabisforskningen, idet man fandt, at endocannabinoider er ansvarlige for formidlingen af kommunikation imellem synapser. Endocannabinoider virker som budbringere for centrale synapser i nervesystemet. Det interessante er, at kommunikationen foregår tilbagegående (retrograde signaling), da endocannabinoider først bliver frigjort af postsynaptiske neuroner. Den frigjorte endocannabinoide rejser baglæns over synapsen og aktiverer præsynapsen, CB1 cannabinoid receptor. Den regulerer dermed præsynaptiske funktioner. Før opdagelsen havde neurofysiologer ledt i over et årti efter en potentiel kandidat, som skulle være ansvarlig for denne handling.
Aktiverer dit endocannabinoide system
Opdagelsen af endocannabinoide-signalering er vigtig, idet den bidrager til vigtige neurologiske funktioner og kan være svaret på, hvorfor cannabisplanten, under den rette behandling, kan have en positiv effekt på autisme og neurodegenerative sygdomme såsom Alzheimers, Parkinsons, MS, hjerneskader, samt Huntingtons.
Kliniske studier viser, at aktivering af det endocannabinoide system kan være effektivt ved behandling af psykiske lidelser, der relaterer sig til frygthukommelser, såsom panikanfald, fobier, og posttraumatisk stress (PTSD). Lignende studier har fundet, at cannabinoider kan virke antidepressivt og angstnedsættende.
Gå efter hampeprodukter, der er kvalitetstestet
For at inddrage hampen i din hverdag, uden at blive kriminel, skal du kigge efter almindelige fødevarer, der holder sig inden for de grænseværdier for THC, det euforiserende stof, som for nylig er sat af Fødevarestyrelsen. Der er udmærket erfaring med Sana Hemp Juice og Dutch Harvest Hemp Te, som er nemme at gå til og anvende.
- Exogene Cannabinoider: Samlet betegnelse for de virksomme stoffer, som er unikke for cannabisplanten. Der skal skelnes mellem tre forskellige slags cannabinoider.
- Syntetiske cannabinoider: Anvendes farmaceutisk i medicinsk cannabis. Ofte er det et enkelt virkestof, der ekstraheres og isoleres fra planten.
- Phytocannabinoider: Naturligt forekommende cannabinoider i cannabisplanten. En phytokemikalie.
- CBD / CBD-a: Kort betegnelse for cannabidiol og cannabidiol-syre. En phytocannabinoide, der forekommer naturligt i planten. Det virksomme stof, som ikke virker euforiserende.
- THC / THC-a: THC er det euforiserende stof, som er ulovligt i de fleste lande. THC-a findes i rå cannabis og er ikke-euforiserende. Den bliver først omdannet til THC under opvarmning.
- Endocannabinoider: Endogene ligander for cannabinoide receptorer. Endogent betyder, at det er medfødt. Endocannabinoider kan stimuleres af exogene cannabinoider og indgår i et netværk af endocannabinoider i kroppen, et såkaldt Endocannabinoide System. Endocannabinoider optager exogene cannabinoider via to cannabinoide receptorer i kroppen, CB1 og CB2.
- CB1, den førstopdagede (1991) cannabinoide receptor i kroppen. Forekommer primært i centralnervesystemet.
- CB2, den næstopdagede (1993) cannabinoide receptor i kroppen. Forekommer hyppigst i immunsystemet.
Det er primært THC, der binder sig til CB1. Smertelindring kan derfor ses næsten omgående ved indtagelse af THC, da THC binder sig direkte til CB1. Det betyder, at den fungerer som en nøgle, der låser op for kroppens egne endocannabinoide receptorer. CBD kan også binde sig til CB1, men den binder sig primært til CB2, som findes i immunsystemet. Det kan muligvis forklare, hvorfor CBD virker antiinflammatorisk samt dens positive indvirkning på vores immunsystem. CBD binder sig indirekte, dvs. at behandlingen med CBD sker gradvist og kan tage op til flere måneder for at opnå en terapeutisk virkning.
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