Dansk navn: Venustorn
Engelsk navn: Devil’s Claw
Tysk navn: Teufelskrale
Familie: Pedaliaceae
Droge: Rodknolde
Beskrivelse
Planten er en ca. 2 m lang, hen ad jorden krybende plante med rødlige, tragtformede blomster. Primroden går omkring 2 m ned i jorden, hvorfra der går vandrette udløbere, som ender i op til 25 cm lange og 6 cm tykke rodknolde. Vokser i Kalahariørkenen og på de Namibiske sletter i det sydvestlige Afrika.
Aktive indholdsstoffer
Rodknoldene indeholder 0,5 til 3% bitre iridoid-glukosider (bl.a. harpago sid), fenol glykosider (acetosid og isoacetosid), 51% kulhydrat, triterpener (bl.a. oleansyre), physterol, fenolsyrer og flavonolglykosider. Indeholder desuden baser, fedtstoffer, voks, gummiharpiks, æteriske olier og en lille smule harpagoquinon.(1) Det er de iridoide glykosider, især harpagosid, der er de inflammations-hæmmende stoffer i roden. Stærk syre kan neutralisere stoffernes effekt, og det anbefales derfor, at Harpagophytum procumbens tages en time før måltider for at nedsætte mavesyrens skadelige effekt. I modsætning til almindelige ikke-steroid inflammationshæmmende medicin, hæmmer Harpagophytum procumbens ikke direkte produktionen af prostaglandiner(4), men har indflydelse på de mekanismer, der kontrollerer calciums indstrømning ind i cellerne. Calciums indstrømning regulerer musklernes sammentrækning og har også indflydelse på blodtrykket og hjerterytmen. Ubalance i calciums ind-og udstrømning kan føre til arytmi. Harpagophytum procumbens beskytter mod arytmi (bl.a. arytmi forårsaget af digoxin forgiftning) og forhøjet blodtryk.(5, 6) Derudover aktiverer calciums indstrømning også enzymet phosphorlipase A2. Dette enzym trigger en kaskade af reaktioner, der producerer inflammatoriske eicosanoider (prostaglandiner). Mange inflammationshæmmende og smertestillende stoffer virker ved at regulere indstrømningen af calcium og dermed hæmme phosphorlipase A2. Det er sandsynligt, at Harpagophytum procumbens også indeholder andre stoffer med inflammationhæmmende egenskaber.(1) Det er en kombination af de iridoide glykosider, triterpenerne og flavonoidet lutein, der giver Harpagophytum procumbens dens hæmodynamiske og elektrofysiologiske virkninger.(7)
Kliniske forsøg
Et forsøg med 630 patienter, der led af forskellige gigtsygdomme, blev behandlet med Harpagophytum procumbens. 42% til 85% af patienterne fik det signifikant bedre efter behandling i 6 måneder. Forbedringsprocenten afhang af hvilke led, der var sygdomsramte; gigt i rygsøjlen eller de store vægtbærende led havde den bedste forbedring.(8) Harpagophytum procumbens er også effektiv i behandlingen af dårlig ryg.(9) 118 patienter, der havde søgt lægehjælp p.g.a. af kronisk dårlig ryg, blev behandlet med et ekstrakt svarende til 6 g af den tørret rod af Harpagophytum procumbens. Det var tilladt patienterne at anvende et smertestillende stof (Tramadol) under forsøget. Placebogruppen modtog ikke Harpagophytum procumbens, men måtte anvende Tramadol efter behov. Efter fire ugers behandling var ni ud af 51 patienter i forsøgsgruppen smertefrie, mens kun een ud af kontrolgruppen var smertefri. Patienter, der samtidigt led af iskiassmerte (sandsynligvis fra en diskusprolaps), havde næsten ingen forbedring. Et andet forsøg undersøgte Harpagophytum procumbens og fordøjelsessystemet. Urten normaliserer både forstoppelse og diarre, eliminerer tarmluft og stimulerer appetiten.(10)
Egenskaber
Inflammationshæmmende, smertestillende, bitter tonic, modvirker arytmi, blodtrykssænkende.(1)
Indikationer
- Gigt: Ledegigt, ledinflammation, sene-skedehindebetændelse, lumbago, myoser, spondylose, podagra.(1)
- Mavetarmkanalen: Dårlig fordøjelse, manglende appetit, diarre, forstoppelse.(1-3)
- Kredsløbet: Arytmi, forhøjet blodtryk, iskæmisk hjertesygdomme, digoxin forgiftning. Migræne.(1, 2)
Kontraindikationer
Harpagophytum procumbens bør ikke anvendes under svangerskab eller i behandlingen af mavesår.(3)
Bivirkninger
Normalt ingen bivirkninger ved anbefalet dosering, men kan forårsage fordøjelsesforstyrrelser hos sensitive patienter, specielt i de høje doseringer.
Toksicitet
Ingen giftvirkninger ved anbefalet dosering.(10)
Dosering
Tørret droge: 1‑6 g tre gange daglig.(2) Gigt og andre sygdomme med inflammation, hjertesygdomme: Ekstrakt (1:2) 40-80 ml ugentlig.(2) Mavetarmsygdomme: Ekstrakt (1:2): 5-10 ml ugentlig.(11)
Kombinationsforslag
Kan blandes med Rehmannia glutinosa, Guaiacum officinalis, Glycyrrhiza glabra, Curcuma longa, Larrea mexicana, Apium graveolens, Tanacetum parthenium, Bupleurum falcatum, Corydalis ambigua, Piper methysticum, Salix arter i behandlingen af leddegigt.
Referencer
1. Bone, K: MediHerb Professional Newsletter, 55, (1997) 2. Bone, K: MediHerb Professional Newsletter, 56, (1997) 3. Bradley, P.R.(ed.), British Herbal Compendium, Vol.1, Dorset: BHMA. 1992, s. 78-80 4. Whitehouse, L. W. : Can Med Assoc J, 129, 249 (1983) 5. Occhiuto, F.. et al: J Ethnopharmacol, 13, 201, (1985) 6. Circosta, C. et al: J Ethnopharmcol, 11, 259, (1984) 7. Occhiuto, F. og de Pasquale, A.: Pharmacolol Res, 22, Supp. 3, 1, (1990) 8. Belaiche, P. : Phytotherapy, 1, 22 (1982) 9. Chrubasik, S. et al: Phytomedicine, 3, 1 (1996) 10. Scientific Committee of ESCOP: ESCOP monographs: Harpagophyti Radix, European Scientific Cooperative on Phytotherapy, The Netherlands (1996) 11. MediHerb, 31st May 1995 Dose Report, ikke udgivet
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