Engelske navne: Winter Cherry, Indian Ginseng
Indisk navn: Ashvaghanda
Familie: Solanaceae
Droge: Rod, blade
Beskrivelse
Findes i de subtropiske, tørre dele af Indien og Mellemøsten, specielt i øde områder i Himalayabjergene op til 5500 m over havet. Lille busk op til 5 m høj, stængler og grene dækket med et lag af stjerneformede hår. Blomstrer næsten året rundt. 10 cm lange, ovale blade. Runde røde bær. Kaldes også for “Fattigmandens Ginseng”. Ashvaghanda betyder “det som lugter som en hest”, giver styrke og seksuel drift som en hest.
Aktive indholdsstoffer
0,2% alkaloider (bl.a. isopelietierin og anaferin), steroid lactoner (withanolider og withaferi ner), sterol saponiner, jern.(1)
Farmakologi
Alkaloiderne nedsætter blodtrykket, stimulerer åndedrættet, løsner kramper i tarmene, livmoderen og bronkierne(1, 2) De steroide lactoner virker desinficerende, anticancer, inflammationshæmmende, beskytter leveren imod tetraklorkul-stof(1,4), og fremmer dens glykogendeponering.(1,5) Withania somnifera nedsætter binyrebarkens forbrug af C‑vitamin og kortisol.(6) Urten hæmmer GABA og TBPS og fremmer flunitrazepans evne til at binde sig til deres receptorer. Urten har også en GABA-mimetisk aktivitet.(8) Et forsøg har vist, at Withania somnifera reducerer 5-hydroxytryptophan og glutaminsyre, men hæver blodets indhold af GABA og monoamin oxidsase. 34 patienter med angstneuroser fik det signifikant bedre efter 12 ugers behandling.(9)
Egenskaber
Adaptogen, styrkende, afslappende, blodtryksnedsættende, inflammationshæmmende, nedsætter hjertebanken, hæmmer cancer (stor dosering), fremmer væksten hos børn og teenagere.(1-3)
Indikationer
- Sygdomsforebyggelse
Withania somnifera virker generelt forebyggende imod kræft og andre sygdomme. Drogen virker forebyggende imod bivirkningerne fra kemoterapi.(1) - Stress og angst
Urten anvendes i behandlingen af udmattelse, “svage nerver”, stress, underernærede børn, blodmangel og impotens.(1) Angst, angstneurose.(8, 9) - Kronisk inflammation
Withania somnifera anvendes også i behandlingen af kroniske inflammatoriske sygdomme som f.eks. bindevævssygdomme (LED, ankylosing spondylitis) og gigt.(1) - Styrkende
Withania somnifera virker styrkende på atleter, ældre, børn og gravide kvinder (stimulerer også mælkeproduktionen).(1)
Kontraindikationer
Ingen kendte.(3)
Bivirkninger
Ingen bivirkninger ved anbefalet dosering.(3)
Toksicitet
Withania somnifera har meget lav giftvirkning og kan bruges gennem længere tid.
Dosering
Tørret droge: 1‑2 g tre gange daglig.(3) Ekstrakt (1:2) i 45% alkohol: 35‑90 ml ugentlig.(7)
Kombinationsforslag
Withania somnifera kan blandes med Glycyrrhiza glabra, Panax ginseng og Scutellaria lateriflora i behandlingen af kronisk stress, udmattelse og impotens. Blandes med Angelica sinensis og Urtica arter i behandlingen af blodmangel.
Referencer
1. Bone, K., MediHerb ProfessionalNewsletter, Aug. (1992) 2. Bone, K., Burgess, N., McLeod, D., How To Prescribe Herbal Medicines, 2.ed. Warwick: MediHerb Ltd., (1992), s. 69 3. Bone, K., Post Graduate Course in Phytotherapy, Warwick: MediHerb (1990) 4. Singh, N., et al Quart. J. Drug Res, 16, 8-16 (1978) 5. Kurandikar et al Ind. Drugs, 23, 133 (1986) 6. Singh, N., et al Int. J. Crude Drugs Res, 29-35 (1982) 7. MediHerb, 31st May 1995 Dose Report, ikke udgivet 8. Mehta AK, et al: Ind J Med Res, 94 (B):312-5, (1991) 9. Upadhaya L. Et al: Acta Nerv Super, 32 (1):1-5, (1990)
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