Engelsk navn: Small Indian Ipecac
Indisk navn: Gurmar
Familie: Asclepiadaceae
Droge: Blade
Beskrivelse
Slyngplante fra Indiens regnskove. Små ovale, behårede blade, små gule blomster. Gurmar, The Sugar Destroyer, er blevet anvendt i over 2000 år i Indien mod sød urin.
Aktive indholdsstoffer
Gymneminsyre, en kompleks blanding af mindst ni beslægtede glykosidsyrer, der bl.a. indeholder glukose og glucuronsyre.(1)
Farmakologi
Virker helbredende på ødelagte Langerhanske øer i bugspytkirtlen(2) og fremmer deres evne til at producere mere insulin.(3) Urten stimulerer desuden enzymer, der fremmer leverens, nyrernes og musklernes optagelse af glykogen og protein dannet henholdsvis via glykogenese og gluconeogenese.(4) Fremmer levetiden for rotter med fremskreden og toksisk diabetes (alloxanforgiftet).(5) Gymnema sylvestre anvendes i behandlingen af insulin-afhængig diabetes. Drogen nedsætter behovet for insulin ved at reducere det fastende blodsukker, glykosyleret hæmoglobin og blodlipider efter 6 til 24 måneders indtagelse.(6) Kan også hjælpe sukkersyge patienter, der er uafhængige af insulin.(7) Urten bedøver de søde smagsløg i adskillige timer efter indtagelse.(8)
Egenskaber
Blodsukkersænkende, astringerende, mildt vanddrivende, styrkende.
Indikationer
- Sukkersyge: Gymnema sylvestre blandet med Galega officinalis og Trigonella foenum‑graecum (Bukkehornsfrø), anvendes i behandlingen af sukkersyge. Bedste resultater opnås, hvis bugspytkirtlen er delvis intakt. Anvendes som støttemiddel og til forebyggelse af sukkersygens følgesygdomme hos insulinafhængige patienter. Gymnema sylvestre anvendes også i behandlingen af patienter med sukkersyge, der er uafhængige af insulin. Eventuel overvægt må nødvendigvis også behandles.(1)
- Overvægt: Gymnema sylvestre fremmer effekten af slankediæter (6 dråber af Gymnema sylvestre‑ekstrakt direkte på tungen en halv til en hel time før et måltid formindsker appetitten) og hjælper atleter med at øge deres muskelmasse i forhold til fedt.(9)
- Hypoglycæmi: Lav dosering kan stablilisere blodsukkeret i tilfælde af ustabilt eller svingende blodsukker.
Kontraindikationer
Større doseringer i hypoglycæmi.
Bivirkninger
Patienter med sukkersyge bør nøje måle deres blodsukker, da Gymnema sylvestre kan fremme effekten af insulin og blodsukker-nedsættende medicin, specielt efter motion.(1)
Toksicitet
Ingen giftvirkninger ved anbefalet dosering.
Dosering
Tørret droge: 1‑3 g tre gange daglig.(10) Ekstrakt (1:1) i 25% alkohol: 25‑75 ml ugentlig.(11) Hypoglycæmi: 5-10 ml ugentligt.(12) Sukkertrang: 1-2 ml dagligt (fordelt i mindre doseringer med 2 til 3 timers mellemrum). Dråberne anbringes direkte på tungen og skylles ud med vand efter et minuts tid.(12)
Kombinationsforslag
Gymnema sylvestre kan også blandes med Glycyrrhiza glabra og Scutellaria baicalensis i behandlingen af sukkersyge. Urterne hæmmer enzymet aldosereduktase, som omdanner glukose til giftige sukkerstoffer (sorbitol og dulcitol), der bl.a. forårsager grå stær hos diabetikere.
Referencer
1. Bone, K., Burgess, N., McLeod, D., How To Prescribe Herbal Medicines, 2.ed. Warwick: MediHerb Ltd., (1992), s. 40 2. Shanmugasundaram, E.R.B. et al J. of Ethnopharmacology 30, 265‑279 (1990) 3. Shanmugasundaram, K.R. & Panneerselvam, C. Pharmacological Research Communications, Vol.13, 475 (1982) 4. Shanmugasundaram, K.R. et al. J. of Ethnopharmacology 7, 205‑234 (1983) 5. Srivastava Y. et al Int. J. Crude Drug Res. 24, 171‑176 (1986) 6. Shanmugasundram, E.R.B. et al J Ethnopharmacology 30, 281‑294 (1990) 7. Baskaran, K et al J. Ethnopharmacology 30, 295‑305 (1990) 8. Warren, R.P. & Weninger, M.G. Nature Vol.223, July 5th, pp.94‑95 1969) 9. Bone, K., The Modern Phytotherapist, Vol.1, No.2, Summer 1995 10. Bone, K., Post Graduate Course in Phytotherapy, Warwick: MediHerb (1990) 11. MediHerb, 31st May 1995 Dose Report, ikke udgivet 12. Bone, K.: Chinese and Ayurvedic Herbs, MediHerb, s. 21,(1995)
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